The San Francisco 49ers picked up a huge win in the NFC wild-card race on Monday night over the Carolina Panthers.

The Panthers will be visiting the San Francisco 49ers on Monday Night Football, which amounts to the biggest regular season game for this franchise since Cam Newton injured his shoulder against the Pittsburgh Steelers in a Thursday night prime-time game back in 2018.

Monday Night Football schedule, TV channel, time, streaming information for Carolina Panthers vs San Francisco 49ers NFL Week 12 game Nov. 24, 2025.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

NFL Insider Ian Rapoport reports that the San Francisco 49ers have voided 2026 guaranteed money in wide receiver Brandon Aiyuk's contract while also providing an update on his recovery timeline from his torn ACL that was suffered last season.

Is Brandon Aiyuk done in San Francisco? Jay Glazer shared why the wide receiver is on thin ice with the 49ers.

Led by Bryce Young, the Panthers have exceeded expectations to this point in the season/ Following Sunday night’s Bics’ loss, Carolina is now tied for first in the NFC South. They also are a single game behind San Francisco for the final Wild Card spot in the playoffs.

San Francisco 49ers star tight end George Kittle reflects on the blockbuster trade with the Carolina Panthers to land Christian McCaffrey.