A drug that has been used to slow progression of kidney and cardiovascular disease in people with type 2 diabetes may also help people with chronic kidney disease who do not have diabetes, according ...
Testing for aldosterone levels may hold the key to treatment-resistant hypertension and many other cardiac conditions, but ...
In the previous issue of the Journal, Mulè et al. 1 report the results of a cross-sectional study aimed at assessing (1) plasma aldosterone concentrations and left ventricular mass (LVM) in essential ...
Please provide your email address to receive an email when new articles are posted on . Mineralocorticoid receptor antagonists, particularly the most recently approved agent finerenone, should play a ...
Aldosterone/NaCl-induced renal and cardiac fibrosis is modulated by TGF-β responsiveness of T cells
We examined the contribution of transforming growth factor (TGF)-β-T-cell signaling to aldosterone (aldo)/salt-induced fibrosis in the kidneys and the hearts of FVB/N wild-type (WT) or transgenic (Tg) ...
Phase II results demonstrated significant albuminuria reductions by up to 39.5% vs. placebo when BI 690517, a novel selective aldosterone synthase inhibitor, was given on top of empagliflozin, an ...
Higher serum aldosterone levels among patients with chronic kidney disease (CKD) are independently associated with an increased risk for CKD progression and end-stage kidney disease (ESKD) regardless ...
The investigational aldosterone synthase inhibitor lorundrostat demonstrated efficacy in reducing systolic blood pressure and ...
Credit: Getty Images Investigators report promising results from a phase 2 trial of an investigational aldosterone synthase inhibitor. Combining the aldosterone synthase inhibitor with empagliflozin ...
Researchers have linked higher levels of the hormone aldosterone to high blood pressure and blood vessel disease in African-Americans. Aldosterone is secreted by the adrenal glands and causes salt ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 50 (Dec. 14, 2004), pp. 17434-17439 (6 pages) WNK1 belongs to a unique family of Ser/Thr kinases that ...
Dr. Aaronson answers the question: 'Aldosterone Antagonist Side Effects?' — -- Question: What are the benefits and side effects of an aldosterone antagonist? Answer: Thanks to research led by Dr.
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