Patients with non-small cell lung cancer (NSCLC) whose cancer cells have low levels of aneuploidy - an abnormal number of chromosomes - tend to respond better to immune checkpoint inhibitor drugs than ...

Some reports suggest that women with abnormal ovarian function produce disproportionally more aneuploidy embryos. [5] If this is true, then the finding of abnormal ovarian function could serve as a ...

Cancer cells with extra chromosomes depend on those chromosomes for tumor growth, a new Yale study reveals, and eliminating them prevents the cells from forming tumors. The findings, said the ...

Assessing tumor-infiltrating immune cells and outcomes with cisplatin- versus carboplatin-based treatment in advanced urothelial cancer (UC): Survival analysis of three platinum-treated UC cohorts.

Aneuploidy (trisomy or monosomy) is the leading genetic cause of pregnancy loss in humans and results from errors in meiotic chromosome segregation. Here, we show that the absence of synaptonemal ...

Yale scientists have discovered a new potential treatment avenue to fight cancer. Using CRISPR gene-editing, the team eliminated extra chromosomes from cancer cells and found that they could no longer ...

The updated statement, "Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics," will be published in the ...

Prenatal testing is widely recommended and widely used to screen for chromosomal abnormalities. Down syndrome (trisomy 21), Edwards syndrome (Trisomy 18) and Patau syndrome (Trisomy 13) are three ...

Researchers provide a comprehensive overview of prenatal screening for fetal aneuploidies, including traditional serum screening, ultrasound imaging, and cell-free DNA testing. A 37-year-old pregnant ...