Methodological developments in biomedical research are currently moving towards single-cell approaches. This allows for a much better spatial and functional characterization of, for example, the ...

Cells can spontaneously change shape even without external signals, but the underlying mechanisms behind this form of ...

Biomedical research typically follows a familiar path: developing treatments that block, enhance or mutate certain signaling pathways, genes or proteins to change the function of different cells in ...

Human cells are organized across a spatial hierarchy of components, ranging from small protein complexes at the scale of nanometres to large condensates, compartments and organelles at the scale of ...

Taking images of tiny structures within cells is tricky business. One technique, cryogenic electron tomography (cryoET), shoots electrons through a frozen sample. The images formed by the electrons ...

Both images show individual red blood cells. The one on the right, produced by STED, more clearly shows the Piezo1 proteins (in green), which are a mechanical calcium channel and play a crucial role ...

Deep inside a small, windowless room at the University of California, Berkeley, two microscopes are quietly capturing some of ...

A new method developed at Baylor College of Medicine and collaborating institutions allows researchers to better understand how RNA works. The method, published in Molecular Cell, is a powerful ...

Introduction Sjögren’s disease (SjD) is a systemic, rheumatic autoimmune disorder evidenced by broad organ-specific ...