Junha Cha and Insuk Lee review computational frameworks that construct reference-based and de novo cell-type-specific gene ...

Gallstone disease is common, but its genetic basis remains incompletely understood. Here, the authors conduct a trans‑ancestry GWAS identifying 116 risk loci, linking gallstone susceptibility to lipid ...

A review outlines how three decades of Parkinson disease genetic discoveries are advancing precision medicine, targeted ...

Researchers at the University of Oklahoma are advancing the fight against inherited retinal diseases (IRDs) with new genetic research that aims to improve diagnoses and lay the groundwork for future ...

There are some 80 human diseases that in one way or another are considered autoimmune. Perhaps the most common indication of an autoimmune pathogenesis is the presence of circulating antibodies that ...

Research on Tourette’s indicates that the condition is strongly influenced by inherited genetic factors, with environmental factors also contributing to its development. Tourette syndrome is a ...

Psychiatric disorders often overlap and can make diagnosis difficult. Depression and anxiety, for example, can coexist and share symptoms. Schizophrenia and anorexia nervosa. Autism and attention ...

The program of Genetic Epidemiology and Statistical Genetics (PGSG) studies the genetic causes of complex human diseases. By uncovering the molecular mechanisms behind diseases, the program aims to ...

Researchers have found that motor delay and low muscle tone were common signs of an underlying genetic diagnosis in children with neurodevelopment disorders. In a new study, UCLA Health researchers ...

IgA vasculitis is a pediatric disease with skin and systemic manifestations. Here, the authors use multiomic data to examine the genetic mechanisms of IgA vasculitis and find therapeutically relevant ...