Histone modification is an epigenetic mechanism that enables fine-tuning of gene expression. Mutation or dysregulation of proteins associated with histone modification (called “writers,” “erasers,” ...

Researchers have determined whether a specific chemical modification of a protein that packages the genome called a histone affects gene activity and cell proliferation. Researchers have determined ...

Researchers at Baylor College of Medicine and collaborating institutions are challenging the traditional understanding of how ...

Peptidyl-arginine deiminase 2 (PAD2) enzyme converts arginine amino acid residues in histone proteins into citrulline groups and promotes tumor cell proliferation in pancreatic ductal adenocarcinoma, ...

Before a newly synthesized protein can undergo folding, it must be processed and transported to the correct location within the cell after emerging from the ribosome. N-terminal acetylation ...

Every cell type in the human body carries the same approximately 3.2 billion base pairs of DNA, yet a liver cell behaves nothing like a neuron. The epigenome explains this difference: in each cell, ...

Cancer has often been explained through mutations in deoxyribonucleic acid (DNA) or changes in ribonucleic acid (RNA), but ...