Targeted Oncology

IGF-1 and GLP-1 Shape Liposarcoma Development, Presenting Potential Targets

Dedifferentiated liposarcoma lacks effective IGF-1→PPAR-γ adipogenic signaling due to epigenetic silencing of PPAR-γ2, with ...
Medscape

Targeting Cancer Cells -- More Pathways, More Inhibitors, More Trials

The insulin and the IGF-1 pathway are closely intertwined. Both can bind the insulin receptor or the IGF receptor 1 (IGFR-1). IGF-2, on the other hand, can bind either IGFR-1 or the high-affinity IGFR ...
Targeted Oncology

Erica Pimenta, MD, PhD

Erica Pimenta, MD, PhD, is an instructor at Harvard Medical School and physician-scientist at Dana-Farber Cancer Institute Erica Pimenta, MD, PhD, discussed the goals and key findings from her and her ...
ascopubs.org

Evaluating the role of preoperative plasma insulin-like growth factor 1 (IGF-1) as a predictor of survival and recurrence in patients with resectable hepatocellular carcinoma.

Comparative outcomes of systemic therapy vs. locoregional therapies in hepatocellular carcinoma with portal vein thrombosis. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This ...