A new study shows that lipid nanoparticles restructure their membrane significantly after being absorbed into a cell and ending up in an acidic environment. (Nanowerk News) Vaccines and other ...

Lipid nanoparticles address key drug delivery challenges, including immune evasion, toxicity, and regulatory approval.

Better mRNA release inside cells boosts vaccine and gene editing performance, enabled by redesigned lipid molecules that grip cargo tightly but let go quickly once inside cells. For vaccines, this was ...

Postdoctoral fellow and co-first author Dongyoon Kim demonstrates some of the equipment used to craft the new ionizable lipids. The most common side effects of mRNA vaccines like the COVID-19 shot are ...

Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without laboratory cell manufacturing and ex vivo expansion. The method using targeted ...

Most people don’t enjoy getting shots for treatments or vaccines. So, researchers are working to create more medicines, such as those made from messenger RNA (mRNA), that can be sprayed and inhaled. A ...

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to steer the particles toward lymph nodes while reducing off-target delivery ...

Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases. ANGPTL3 loss-of-function genetic variants are associated with decreased levels of low-density lipoprotein ...

Malvern Panalytical’s recent peer-reviewed publication, Tailoring Lipid Nanoparticle Dimensions Through Manufacturing Processes, published in RSC Pharmaceutics, features both the NanoSight Pro ...

The most common side effects of mRNA vaccines like the COVID-19 shot are well known: soreness, mild fever, and general malaise. Those symptoms, which typically resolve within days, are the natural ...

Researchers hold models of the aromatic rings they added to lipid nanoparticles, which could reduce the dosage mRNA vaccines need to achieve immunity. Penn Engineers have redesigned a key component of ...