The complement system protects against infection, positively responds to tissue damage, clears cell debris, directs and modulates the adaptive immune system, and functions in neuronal development, ...

The complement system was first identified in the late nineteenth century as a heat-labile component of serum that ‘complements’ the antimicrobial activity of antibodies. Since then, it has become ...

Agents of transmissible spongiform encephalopathies (TSEs) usually enter the body via a peripheral route and replicate in lymphoreticular tissues before moving into the brain. Any impairment of the ...

AJMC ®: How has treatment of complement-driven diseases changed since 2007, when the first complement inhibitor, eculizumab, was approved? SMITH: The development of eculizumab followed our ...

Complement 3 glomerulopathy (C3G) is a rare kidney disease that affects your body’s innate immune system (complement system). Complement 3 glomerulopathy (C3G) is a kidney disease that’s caused by ...