In the modern NFL, safety play is destiny. If Brown has leveled up alongside the equally violent Malik Mustapha, the Niners ...

McCaffrey made history again in Monday’s game, prompting a big announcement from the NFL.

San Francisco 49ers safety Ji'Ayir Brown had his best game of the season in their win over the Carolina Panthers on Monday.

Mac Jones joined Jeff Garcia and Steve Young in the 49ers’ record book during Sunday’s 42-26 loss to the Los Angeles Rams.

The 49ers will be without record-setting kicker Eddy Piñeiro against the Panthers, as San Francisco rules him out for Monday ...

The Carolina Panthers and San Francisco 49ers meet for Monday Night Football in Week 12. Kickoff from Santa Clara is scheduled for 8:15 p.m. ET.

The San Francisco 49ers will take wins where they can get them after injury woes threatened to derail their season. But Brock ...

Teams looking to stay in the mix in their respective divisions clash when the Carolina Panthers battle the San Francisco ...

The 49ers and Panthers are in the thick of the NFC playoff race. USA TODAY Sports provided updates, highlights and more from "Monday Night Football." ...

Week 12 will conclude in Santa Clara when the San Francisco 49ers host the Carolina Panthers. It's a game stocked with ...