Following a slate with several marquee matchups, NFL bettors will see three double-digit spreads on the Week 12 schedule.

Week 12 is low on high profile matchups. The NFC North, however, might just be the NFL's most interesting division.

Sam Farmer makes his picks and score predictions for Week 12 of the NFL season, with Patrick Mahomes and the Chiefs winning at home over the Colts.

Check out our NFL Week 12 picks for the 14 NFL games this week, a week that begins with the Buffalo Bills at Houston Texans on Thursday Night Football on Nov. 20 and ends with the Carolina Panthers at San Francisco 49ers on Monday Night Football on Nov. 24.

The Patriots look to move to a 10-2 record today against the struggling Bengals. Our Patriots vs. Bengals expert predictions highlight the best betting picks for the AFC clash.

Thanksgiving marks the start of the home stretch of the NFL season, which means we’re only a week away from the start of the proverbial Witching Hour, as Scott Hansen would call it. And this slate starts strong, with a Buffalo Bills vs. Houston Texans ...

This week is ripe with seven eligible games, including three double-digit spreads. The underdogs in those games have a combined record of 5-26: N.Y. Jets 2-8, Giants 2-9 and Titans 1-9, and the combined spread is 37.5 points. Not surprisingly, Jess and I avoided those three games.

Mike Florio and Chris Simms preview a Week 15 duel between the Titans and 49ers at Levi's Stadium, explaining why San Francisco is "quietly lurking" and should beat Tennessee.