ESPN announced a major change for the Week 16 showdown between the San Francisco 49ers and Indianapolis Colts.

Most Wednesdays, ESPN P.R. posts a tweet boasting about the audience generated by the NFL game televised two nights earlier.

The San Francisco 49ers are going to need an X-factor to step up and change the way the team is viewed if they want to make a ...

Christian McCaffrey is making NFL history for the San Francisco 49ers with 1,655 scrimmage yards and top RB receptions ...

Broadcast and streaming information for the San Francisco 49ers Week 12 matchup against the Carolina Panthers at Levi's® Stadium.

Sanders is starting in Week 13 against the San Francisco 49ers, and Garrett gets to go up against Brock Purdy and a shaky ...

The 49ers are fighting for their spot in the NFC playoffs this season. Here's where they stand heading into Week 14 of the ...

After the 49ers’ dominant 20-9 home win over the Panthers, San Francisco receiver Jauan Jennings got into a heated ...

After Brandon Aiyuk's guarantees for next season have been voided, Jeremy Fowler reports that the saga is "far from over" for ...

Levi's Stadium in Santa Clara, California, will be the site of Super Bowl LX in February. It's also the stage for the latest edition of ESPN's "Monday Night Football." Fresh off a franchise-record ...

In an interview with our sister network ESPN, San Francisco 49ers receiver Ricky Pearsall says he was unsure of his fate ...

San Francisco voided the receiver's contract guarantees for next year. What does that mean for this season and beyond?