JSTOR Daily

Amyloid β-Peptide Inhibition of the PKA/CREB Pathway and Long-Term Potentiation: Reversibility by Drugs That Enhance cAMP Signaling

Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 20 (Oct. 1, 2002), pp. 13217-13221 (5 pages) Changes in hippocampal function seem critical for cognitive ...
GEN

Evidence Found that CREB Pathway Is More Complex than Previously Thought

Scientists observed that CREB activates specific genes based on the co-factor involved. Investigators at St. Jude Children’s Research Hospital discovered how a transcription factor called CREB ...
EurekAlert!

Ligustroside derived from Ligustrum japonicum inhibits melanogenesis via blocking the MAPK and PKA/CREB signaling pathways

Mitogen-activated protein kinase (MAPK) and Wnt signaling pathways are critical for melanocyte development and melanogenesis and could be novel therapeutic targets for modulating melanin synthesis.
ALZFORUM

NMDA Receptors Play Good Cop, Bad Cop in Huntington’s Model

NMDA receptors populate the synapse, where they participate in nerve signaling and promote cell survival pathways. But those same receptors, when they spread out into extrasynaptic regions, can ...
JSTOR Daily

Activation of Critical, Host-Induced, Metabolic and Stress Pathways Marks Neutrophil Entry into Cystic Fibrosis Lungs

Cystic fibrosis (CF) patients undergo progressive airway destruction caused in part by chronic neutrophilic inflammation. While opportunistic pathogens infecting CF airways can cause inflammation, we ...