If the 49ers make the playoffs McCaffrey might start to feel the effects of the 400-plus touches he’s on pace for, but that’s ...

It's been a rocky relationship between Brandon Aiyuk and the San Francisco 49ers since their heartbreaking loss in the Super ...

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale ...

Just one year after a massive contract extension, the 49ers and Brandon Aiyuk's relationship may be coming to an end.

The San Francisco 49ers are back at Levi’s Stadium in Week 12 of the NFL season with a “Monday Night Football” matchup set ...

Christian McCaffrey enjoyed a big night after helping the San Francisco 49ers to a 20-9 victory over his former team, the ...

As both teams jockey for position in the playoff standings, the San Francsico 49ers battle the Carolina Panthers on Monday ...

The loss left the Panthers a half-game behind Tampa Bay (6-5) in the division with their next game against the NFC-leading ...

Carolina is coming off an unusual offensive game wherein it did not run the ball particularly well but absolutely exploded in ...

49ers vs. Panthers will be on "Monday Night Football" in Week 12, which will air nationally on both ABC and ESPN. Joe Buck ...

"We do it all the time in practice, so it's not a big deal," Trent Williams said of McCaffrey's untouched TD. "But yeah, it's ...

Despite a challenging season with five losses, the Carolina Panthers, led by quarterback Bryce Young, are set to face the formidable San Francisco 49e ...