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The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.
The Panthers squandered an opportunity on the West Coast. Here’s what you should know following their 20-9 loss.
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49ers vs. Panthers final score, results: McCaffrey stuffs scoreboard against former team, 49ers defense stifles Carolina in 20-9 win
In his first game against his former team, McCaffrey had 142 scrimmage yards and a touchdown as the 49ers won 20-9.
The Panthers were considered big underdogs for tonight's game against Santa Clara, and the oddsmakers were right to think so.
CHARLOTTE — The Carolina Panthers suffered a 20-9 defeat against the San Francisco 49ers on Monday Night Football, struggling with turnovers and missed opportunities.
Dave Canales opened his postgame press conference Monday night disappointed but resolute. “Just a game of missed opportunities,” the Carolina Panthers’ head coach said before being prompted by any question. He’s right.
The Carolina Panthers (6-5) are monitoring nine players on the injury report, including Bryce Young, as they prepare for a Monday, Nov. 24 matchup against the San Francisco 49ers (7-4) at Levi's Stadium, which starts at 8:15 p.m. ET.
Preview the San Francisco 49ers' NFL Week 12 matchup with the Panthers and find out who is on the injury report.
DraftKings offers a $200 bonus if your first bet $5 wager wins and 3 months free NBA League Pass for Carolina vs. San Francisco on Monday Night Football
Preview the Carolina Panthers' NFL week 12 matchup with the 49ers, including betting odds, tips, trends, and game information.
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