Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

Should Guerendo start as expected Sunday, it will be just his second start as a running back since he was in the fourth grade ...

Kyle Shanahan explains why 49ers rookie Isaac Guerendo is ready to be the starter with Christian McCaffrey and Jordan Mason ...

Henry will be the only must-start member of this backfield when they return in Week 15 to face the Giants. James Cook (Week ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

SANTA CLARA — When Isaac Guerendo trots on to the field with the first team Sunday at Levi’s Stadium, he will equal the same ...

Rookie Isaac Guerendo is set to start at running back in the San Francisco 49ers’ Week 14 clash with the Chicago Bears this ...

Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

San Francisco 49ers running back Isaac Guerendo discussed being the "next man up" with Christian McCaffrey and Jordan Mason expected to miss significant time due to injury.

Isaac Guerendo will make his first NFL start on Sunday as the injury-depleted San Francisco 49ers face the Chicago Bears. The ...

The San Francisco 49ers are moving forward without star running back Christian McCaffrey or backup Jordan Mason for the ...

It’s Week 14, folks! Time to set those fantasy lineups! Start ‘Em, Sit 'Em is the ultimate look at the best and worst matchups in a given week for fantasy footb ...