The Carolina Panthers and the San Francisco 49ers take the field for NFL Monday Night Football tonight in Week 12. MNF start time, schedule and how to watch.

This will surely put them over the top. The Carolina Panthers have announced a pair of moves going into tonight's game with the San Francisco 49ers on ESPN's presentation of Monday Night Football. The Panthers are 6-5 and have a chane to take first place in the NFC South thanks to Tampa's loss to the Los Angeles Rams last night.

The Panthers, who face San Francisco on the road Monday night, have played 18 times on ‘MNF.’ Here’s a list of their four biggest wins.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

Catch Bryce Young and the Panthers (6-5) against Brock Purdy and the 49ers (7-4) at 8:15 p.m. ET on ESPN with streaming options available.

The Carolina Panthers made their first prime-time appearance in an NFL regular-season game since Nov. 9, 2023, on Monday night with an opportunity to take sole possession of the lead in the NFC South.

DFS millionaire Mike McClure shares his top daily fantasy football picks and lineup advice for Panthers vs. 49ers on 'Monday Night Football'